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Glucuronidation pathway In the process of glucuronidation, UDP-glucuronosyltransferases, such as the NRF2-regulated enzyme UGT1A1 [69], transfer the glucuronic acid component of UDP-glucuronic acid onto substrates, including drugs, bilirubin, hormones, and other molecules

TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labelling) staining was performed using In Situ Cell Death Detection Kit

As a result, the phenotype due to genetic mutations is more likely to be manifest in males

[42] reported that anthocyanin-rich Aronia melanocarpa ameliorates chronic alcohol-induced Nrf2 downregulation, reduces antioxidant enzyme levels, and inhibits hepatic fat accumulation and inflammation in mice