As mentioned above, glutathione is deprived with aging, stress, and illness
This mineral not only helps balance thyroid hormone production but is also a crucial component of glutathione peroxidase, a powerful antioxidant enzyme that protects thyroid cells from oxidative stress
However, certain stimuli can disrupt the antioxidant system of the body, leading to oxidative stress reactions triggered by factors such as ROS, resulting in localized or systemic damage (94)
Zinc supplementation restores these functions and activates the membrane-bound GPR39, initiating the Gqphospholipase C (PLC)inositol triphosphate (IP3) signalling cascade
Expression of FSP1 was not altered by Nutlin3 or doxorubicin treatment, whereas the expression of p53 and p21 was strongly induced in HT1080 p53 wild-type cells