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It might be tempting to have some grapefruit anyway if it's been a while since your medication was taken, but its effects can last for a surprisingly long time

The phase 3 OASIS 1 trial investigated high dose oral semaglutide in participants with overweight or obesity, but without T2D (58)

The most common side effects in the trial included: Nausea (about 29 to 42 percent of participants, depending on the dose) Diarrhea (25 to 34 percent) Constipation (24 to 26 percent) Vomiting (11 to 25 percent) Upper respiratory tract infection (12 to 14 percent) These side effects are consistent with other injectable weight loss medications, according to Siegel

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