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ALS is mostly diagnosed based on clinical signs, using the revised El Escorial criteria, which require signs of both upper motor neuron (e.g., spasticity, brisk reflexes) and lower motor neuron damage (e.g., muscle wasting, twitching) in multiple body regions (Brotman et al., 2025)

Screenshots and Data The Markup found 66 listings for peptides available for sale on Amazon in August and September, even though the company bans injectable drugs and told The Markup in May it would start cracking down on peptide listings

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10.1016/S2215-0366(17)30015-9 63