Its a novel drug that functions as a dual agonist, meaning it activates two types of receptors in the body: GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist: This receptor helps regulate blood sugar levels by increasing insulin secretion, decreasing glucagon release, and slowing gastric emptying
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Parent drug accumulated in plasma Greater hERG channel blockade Excessive QT prolongation The Fatal Outcome: Torsades de Pointes (TdP) Excessive QT prolongation predisposes the myocardium to early afterdepolarizations (EADs), which can rapidly progress to: Torsades de Pointes (TdP) Ventricular fibrillation Sudden cardiac death Key Pharmacovigilance Lesson A drug can be highly effective yet become life-threatening when metabolic pathways are disrupted
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Some, like James, have successfully lost significant weightperhaps three or four stones over a year on Wegovyonly to find the scales static for several months