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Treatment guidelines do not give a definite upper limit for basal insulin dose, and there may be the temptation to continue with a familiar routine by increasing the basal insulin dose despite the patient still not achieving glycemic targetsa situation known as over-basalization [10]

A study using human enteroendocrine NCI-H716 cells, published in Nutrition Reviews , found that berberine triggers GLP-1 secretion through exactly this bitter-taste signaling pathway

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Research shows that it lowers blood glucose levels without altering insulin sensitivity