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To reconcile the findings that both GIPR antagonists and GIPRAs reduce body weight, it is possible that physiological GIPR activity plays a permissive role in adipose tissue synthesis, while pharmacologically enhanced GIPR activity may reduce body weight through a different mechanism in the brain

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A network meta-analysis comparing exenatide once weekly with other GLP-1 receptor agonists for the treatment of type 2 diabetes mellitus