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Scientific Reports DOI:10.1038/s41598-026-60835-w Abstract Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO ) generation during aging
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Consequently, this peptide garners the designation N-(trans-3-hexenoyl)-[Tyr1]hGRF(144)NH2 acetate
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We found that TOR1B did not exhibit a significant association with other traits at the genetic level, further confirming the robustness of our results and the safety of tor1b as a therapeutic target (Fig S2)
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