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Observed outcomes include specific cellular and molecular endpoints such as: Enhanced fibroblast migration capacity Increased collagen and elastin deposition Modulation of pro-inflammatory and antioxidant mediators Altered transcriptional profiles related to tissue homeostasis, repair signaling, and stress response All reported observations derive exclusively from preclinical laboratory and animal studies and remain model-specific

EGCG also influences the crosstalk between apoptotic and autophagic pathways through p53 and NF-B, allowing coordinated responses

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The copper ion stabilizes the peptide structure, facilitates cellular uptake, and participates directly in the enzymatic reactions that promote collagen synthesis and tissue remodeling

HS: Writing review and editing, Methodology, Writing original draft