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For instance, Tong et al

Although the primary biological actions ascribed to intact GLP-1 are mediated by a single GLP-1 receptor [28], GLP-1 is rapidly cleaved by the enzyme dipeptidyl peptidase-4 (DPP-4) into GLP-1(9-36) [29], which exhibits its own biological activities (albeit not insulin secretion any more) [30,31], and thus intact GLP-1 exhibits a short half-life of one to two minutes in the circulation [32]

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The KEYNOTE A60 is a multicenter, open-label phase Ib/IIa study of efineptakin alfa (NT-I7, a long-acting IL-7 agonist) in combination with pembrolizumab in patients with refractory advanced solid tumors (NCT04332653)

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