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Extracellular succinate is the ligand that activates the GPCR originally identified as GPR91 but is now referred to as the succinate receptor 1 and is encoded by the SUCNR1 gene

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If fewer people choose to take GLP-1s, that means less revenue for big players like Eli Lilly and Ozempic maker Novo Nordisk

Moreover, although GLP-1 has a significant effect on blood glucose control, its effect on lipid metabolism is relatively weak