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Nutrients (2017) 9:521

Together, these intriguing findings demonstrate that RSL3 can effectively induce DNA damage, impair DNA damage repair response, and trigger autophagy in thyroid cancer cells by inhibiting GPX4

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Uptake transpires by many mechanisms, including clathrin-mediated endocytosis, caveolae-dependent endocytosis, phagocytosis by immune cells, and, at times, direct membrane fusion, contingent upon surface chemistry and particle size [150, 151]

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