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Additionally, melatonin reduced the activities of other kinases involved in tau hyperphosphorylation, such as CDK5, through the upregulation of micro-RNAs [115]

The researchers concluded that most of these hormonal changes (particularly TSH and free T3) appeared to be independent of weight loss, suggesting a possible direct effect of semaglutide on thyroid regulation that still needs to be clarified, while changes in free T4 were more closely related to weight change

he consults for Eisai, Lilly, NeuroTherapia, Signant Health, Novo Nordisk, Anavex Life Sciences, Alzheon, Cognito Therapeutics, GSK and AbbVie

Grove, C

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