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Hippo signaling regulates YAP primarily through large tumor suppressor kinases 1 and 2 (LATS 1/2), which are activated through phosphorylation by mammalian sterile 20-like protein kinases 1/2 (MST1/2)

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( A ) Representative image of 12-week-old ad libitum chow-fed male WT C57BL/6J and Bbs5 / mice

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Game discovery is another differentiator