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How does it feel to take GLP-1s

Real-world impact of adding a glucagon-like peptide-1 receptor agonist compared with basal insulin on metabolic targets in adults living with type 2 diabetes and chronic kidney disease already treated with a sodium-glucose co-transporter-2 inhibitor: The Impact GLP-1 CKD study

Why does this matter

The permeable CVOs enabling the rapid neurohumoral exchange include the subfornical organ (SFO), the area postrema (AP), the vascular organ of lamina terminalis (VOLT), the median eminence (ME), neurohypophysis (NH), the pineal gland (PG), and subcommissural organ (SCO)

These combined mechanisms explain both the glucose-lowering and weight-reducing properties of this medication class