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High doses are often used for short-term, targeted goals, but the delivery methodsuch as liposomal technologyis far more critical for effectiveness than high milligram counts

The resulting elevation in intracellular Ca activates protein kinase C (PKC), which subsequently phosphorylates and activates MEK, ultimately leading to enhanced phosphorylation and activation of ERK1/2 within the MAPK pathway [51] [52](Fig