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In chronic HIV infection, persistent mtDNA leakage sustains this pathway, contributing to the elevated IFN-inflammatory signature characteristic of individuals even on ART

Sandoval and DAlessio (2015)

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Even if l-theaninecaffeine combination appears to be inferior to the currently used stimulants, based on our results, there is a potential to use the combination as an adjuvant to increase the number of stimulant-medication free days to prevent tolerance and to complement the action of currently used medications