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Therefore, promoting the apoptosis of senescent endothelial cells and improving the microenvironment of aged blood vessels is crucial for maintaining vascular function

[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

Now, heres where the magnesium study gets more interesting

It is astonishing that notwithstanding the Tietzes method for glutathione titration is the most cited one in the literature (4111 hits on Scopus database) and most of the commercially available kits are still based on its procedure, his findings and warnings on GSSG values have been rapidly and are still consistently ignored

L., Diekmann, D