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Our data demonstrate that the adaptive metabolic response to 5FU is mediated through the inhibition of TS function, as we recapitulate these phenotypes by genetic silencing or targeted inhibition of TS using antifolates

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The results showed that after FOXO4-DRI treatment, the p-P53/P53 ratio significantly increased in the nucleus, cytoplasm, and total protein samples (Figure 5D)

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