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Importantly, GLP-1 RAs should be prescribed and managed by clinicians experienced in pediatric obesity (e.g., pediatric endocrinologists or obesity specialists) because of dosing complexities and the need for growth monitoring

For semaglutide, that means jumping from 0.25 mg to 0.5 mg

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However, the reason behind the loss of these dopamine-producing nerve cells remains unclear (57)

Your healthcare team can help distinguish between medication-related effects and other causes of joint pain, ensuring you receive appropriate treatment whilst maintaining the benefits of GLP-1 therapy