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Pregnant women, breastfeeding mothers, and people with kidney, liver, or severe respiratory problems should avoid glutathione, as improper supplementation can stress metabolic pathways and increase health risks

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A systematic review found favourable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, bipolar disorder, depression, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy

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