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Hydroxyethyl starch inhibits glycocalyx-degrading enzymes, facilitating the restoration of glycocalyx thickness and enhancing expression of VE-cadherin, occludin, and zonula occludens-1, reducing albuminfluorescein isothiocyanate infiltration, and improving pulmonary vascular permeability [45]

The dosing schedule starts at 0.25mg weekly for the first month, then titrates up gradually to the maintenance dose

Safety, pharmacokinetic, and pharmacodynamic evaluation of a 2-(2-methoxyethyl)-d-ribose antisense oligonucleotide-triantenarry n -acetyl-galactosamine conjugate that targets the human transmembrane protease serine 6

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