This oxidative environment causes mtDNA lesions, mutations, and deletions (82)
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A large GWAS study that included 457,690 individuals (121,289 individuals with CAD and 63,495 individuals with myocardial infarction) showed that genetically determined elevated serum UA level was associated with the increased risk of CAD [OR =1.10 (95% CI: 1.061.15)] and myocardial infarction [OR =1.12 (95% CI: 1.071.18)]
Liang et al., 2024)