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Diabetic Retinopathy Complications in Patients with a History of Diabetic Retinopathy: Rapid improvement of glucose control has been associated with temporary worsening of diabetic retinopathy

doi: 10.1016/j.ando.2012.06.002

This is due to an increased Tac metabolism from a higher CYP3A4 activity as well as an increase in plasma volume next to hypoalbuminemia and anaemia (77)