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[39] What this means is that, disruptions that occur to the gut (for instance, from taking an antibiotic, taking acid-suppressing medications for acid reflux , or eating an inflammatory food like gluten ), can upset the microbiome, cause intestinal permeability ( leaky gut ), and result in a shared gut-brain inflammatory event

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However, long-term aspirin use, particularly in individuals with pre-existing gastric conditions, is associated with damage to the gastric mucosa, ranging from mild mucosal erosion and ulceration to more severe complications, such as bleeding or perforation

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