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Nevertheless, the reverse is also true

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GHRH upregulates the pituitary-specific POU homeodomain transcription factor, Pit-1, which in turn, transcriptionally upregulates the GH1 , GHRHR and Pit-1 genes (auto-upregulation)

IGF-1R inhibition-induced p70S6K1 phosphorylation contributes to cell survival Previously, we showed that Pdcd4 suppresses IGF-1R inhibition-induced p70S6K1 phosphorylation when cells were treated with the IGF-1R inhibitor, OSI-906