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reduced cytosolic Na (via NHE1 modulation) improves Ca handling and tempers mitochondrial ROS

Careful biochemical follow-up testing evaluating progress in response to therapy every 3 months, leading to precision dose adjustments promoting peak benefits

investigated related targets of copper and related mitochondrial functions using copper ionophores such as elesclomol and discovered a copper-induced specific RCD, which they named cuproptosis [9, 145]

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Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism