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Crystal structure of the obese protein leptin-E100

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

The pathogenesis of NDs, such as AD, PD, HD and ALS, is complex and multifactorial, involving oxidative stress, neuroinflammation, mitochondrial dysfunction and protein misfolding/aggregation

In the last decade, technological advancements in techniques such as circular dichroism (65), Cryo-electron microscopy (Cryo-EM) (66) and crystallography (67) have expanded our understanding of the physiology of multiple chemosensors expressed by L-cells, which led to the discovery of new molecular tools with possible future clinical applications in diseases such as type 2 diabetes (64, 6870)