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Examples Roflumilast Apremilast (used in psoriasis and psoriatic arthritis) Common Adverse Effects Nausea Diarrhea Weight loss Headache Insomnia Because of these effects, patient monitoring is important, especially for unintentional weight loss

Xu J, Dydak U, Harezlak J, Nixon J, Dzemidzic M, Gunn AD, et al

The IC50 of CGA for hepatocyte activity was determined to be 613.1 M (Figure 2C)

No mixed disulfide intermediate was detected in accordance with a slow reaction between both proteins that was followed by a rapid intramolecular disulfide bond formation yielding roGFP2 WT (S 2 )

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