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Initial observations regarding the animal model indicated that out of 72 operated rats, 3 died during anesthesia and were subsequently replaced

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The hyperphosphorylation of tau begins in the hippocampus of the mice at 12 months of age and then proceeds to spread to the cortex with NFT structure becoming more apparent by 15 months of age 143

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4 Spicules start behind the iris, especially behind darker irides, due to heat transfer from the iris to the crystalline lens