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Novo Nordisk specifically identified demographics, including men and younger individuals, as being less inclined to use injectables, groups that oral options are particularly likely to engage

Since tirzepatide often produces less nausea at equivalent efficacy, switching may provide the same weight loss with better GI tolerance

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10.1016/j.clinthera.2020.03.013 262

Activated TGF signaling is one mechanism that suppresses lipid oxidation and induces the glycolysis-lactate pathways, thereby promoting mesenchymal metabolic shifts and related fibrogenesis in renal tubules (Srivastava et al., 2018