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MASLD is associated with an increased risk of cardiovascular events, chronic kidney disease, hepatic and extrahepatic malignancies, and liver-related outcomes, including liver failure and hepatocellular carcinoma (HCC)

The full side-effect profile may evolve as larger and longer-duration studies are completed

Injection site selection plays a crucial rolethe abdomen (at least 2 inches from the navel), thigh, and upper arm are FDA-approved sites for most GLP-1 medications, with comfort levels varying between individuals

This can make them easier to tolerate when hunger is low

But millions of Americans struggle with varying degrees of obesity, and the causes are diverse yo-yo dieting strategies, challenges accessing healthy food at an affordable price, individual biological and genetic factors, how our brains are wired, and widespread mental health and substance abuse issues