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Molecular modeling and laboratory studies conducted over the past two decades suggest that the AEDG sequence can bind to chromatin structures , influencing gene expression associated with aging and cellular regulation

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Additionally, ROS can promote endothelial fibrosis, resulting in downregulation of adhesion proteins, thereby compromising endothelial integrity and increasing permeability (48)

Trial 7 Treatment Effect for MACE and its Components Note: Data from the in-trial period based on full analysis set defined as all randomized patients