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Rhonda Patrick: I've seen some not-so-great preliminary evidence suggesting maybe time of day is important

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Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins

Modulation of transforming growth factor-beta (TGF-beta), integrins, and stem cell pathways have also been observed