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They typically improve over time and can include: Nausea Vomiting Diarrhea or constipation Stomach pain Fatigue Serious side effects and warnings Tirzepatide can cause serious side effects, though these are rare

In the sensitivity analysis of our study, when applying the disutility value of 0.0472 per unit increase in BMI, once-weekly semaglutide was associated with greater improvements in quality-adjusted life expectancy (+0.37 QALYs for semaglutide 0.5 mg, +0.82 QALYs for semaglutide 1.0 mg) compared with dulaglutide 1.5 mg

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