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To evaluate the role of BCAA metabolism in propionyl-CoA generation, we employed stable isotope-labeled [ 15 N, 13 C 5 ]valine (M6 valine) to measure the contribution of valine catabolism to propionyl-CoA during fasting conditions

By dividing the total radiation dose into multiple small fractions for treatment, not only can the therapeutic effect on the tumor be maintained, but normal tissues are also given more time for repair and recovery, thereby reducing the risk of long-term neurotoxicity [86, 87]

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