Fusion takes the two bones that form a joint and fuses them together to make one bone
Due to this symmetry mismatch, the bottom of ATD and top of the LBD domains of only the distal subunits are in close apposition and interact with each other unlike the ATD and LBD domains of the proximal subunits
Nakagami H, Cui TX, Iwai M, Shiuchi T, Takeda-Matsubara Y, Wu L, et al
The distinction matters when considering the research required to validate any of them
Phase 2/3 trial of structurally distinct prodrug fosgonimeton (Athira ATH-1017) missed primary endpoint in 2023 Product Specifications Format: capsules Strength: 10 mg per capsule Count: 30 capsules per bottle Purity: 98% (HPLC verified) Container: sealed amber bottle Certificate of Analysis: lot-specific COA available See the FDA Disclosure, Storage Instructions, and RUO tabs for handling, storage, and regulatory information