Monthly follow-ups during titration assess tolerance and effectiveness
Long-term exposure to pollutants like microplastics (MPs) and DEHP promotes excessive ROS production through the CNR1/CRBN/YY1/CYP2E1 axis, oxidizing YAP1, which ultimately leads to necroptosis and impaired ovarian function in granulosa cells (Wu H
Sustained weight loss is better than rapid weight loss Although rapid weight loss can be appealing, losing weight too quickly can increase the risk of fatigue, nutrient deficiencies, muscle loss, and rebound weight gain
This finding is consistent with earlier studies (Rutishauser et al., 1979)
If hypoglycaemia occurs (symptoms include tremor, sweating, confusion, and palpitations), treat with 15-20g of fast-acting carbohydrate (e.g., glucose tablets, fruit juice), retest after 10-15 minutes, and follow with a longer-acting carbohydrate if needed