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Recent trial data demonstrate that these benefits extend to individuals without diabetes, underscoring their role as cardiometabolic therapies rather than purely glucose-lowering medications [50, 51]
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It reduced the pro-fibrotic factor collagen in renal tubular tissue and human proximal tubular cells by inhibiting the NF-B and MAPK signaling pathway in DM
Patients with these risk factors should discuss screening and supplementation strategies with their GP, particularly if experiencing symptoms such as fatigue, paraesthesia, glossitis, or cognitive changes suggestive of deficiency
However, rapid weight loss itself can sometimes trigger temporary shedding, known as telogen effluvium
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