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Critically, in non-senescent cells, this interaction is not a survival dependency, so FOXO4-DRI does not trigger apoptosis in healthy cells

When serine and threonine residues within the C truncation were replaced by alanine (Sec24C MUT), VRK2 could not increase phosphorylation of Sec24C MUT (Fig

doi: 10.1016/j.jobcr.2025.06.006 35 KumarADavuluriGWelchNKimAGangadhariahMAllawyAet al

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Beginners should start at 5 mg once per week and assess tolerance for two weeks before increasing