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It can be an effective medicine to achieve sustained weight loss when used alongside a reduced calorie diet, increased physical activity and healthy lifestyle choices.

Elevated glucose levels activate the enzyme aldose reductase (AR), which transforms glucose to sorbitol, with NADPH serving as a coenzyme for this process

Genetic variation in GLP-1 receptor (GLP1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and appetite regulation genes (MC4R, FTO) influences baseline signaling capacity and treatment response heterogeneity

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About one in five patients taking semaglutide in SELECT had to stop treatment