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Ryan said that "we do need better evidence" around whether some individuals can maintain weight loss after coming off GLP-1s, but she thinks what "Calibrate is doing is sharing the decision-making with the patient and trying to adapt to the environment where drugs may not always be available." Since Calibrate has come onto the market, results were published from a much larger, peer-reviewed study funded by the Ozempic manufacturer Novo Nordisk in 2022

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