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A Phase I Dose-Escalation Study OF PRI-724, A CBP/B-Catenin Modulator In Patients With Advanced Acute Myeloid Leukemia (AML)

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Oxidative stress is also generated by reactive nitrogen species (RNS), which includes nitrate, nitrite, nitric dioxide, nitric oxide, and peroxynitrite

Participants receiving the highest dose of 12 mg lost an average of 24.2% of their body weight, compared to just 2.1% with placebo