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Methionine in turn is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA, RNA, and proteins ( Figure 1 ) (3)

Treatment doses for deficiency are substantially higher, typically involving intramuscular injections of 1,000 g or oral supplementation of 502,000 g daily, depending on the underlying cause and severity

S., Wan, T

Such as the symptoms listed above and on laboratory evaluation