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In a pharmacokinetic trial of 16 epileptic patients maintained chronically on CYP3A4 inducers, carbamazepine, or phenytoin, a reduction in AUC, Cmax, and t of ondansetron was observed

At mid-range doses like 75 units, most patients experience manageable nausea, reduced appetite, and occasional digestive changes that typically improve within one to two weeks

Reaction was finished by addition of detection mix (provided with the assay kit), plates were mixed for 30 minutes and then rested for three hours at RT before counting in a TopCount (Perkin Elmer)

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