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PMID: 165 BoodaghidizajiMJunglesTChenTZhangBYaoTLandayAet al

Free hydrogen radicals diffuse very easily through the polymer matrix and combine in pairs or abstract hydrogen atoms from polymer molecule

Higher-Molecular-Weight Species Orthogonal methods may be needed because reverse-phase HPLC does not identify every aggregate or peptide complex

However, the underlying mechanisms are totally different

The LR3 extension does not make it "safer" -- it makes it longer-acting and less regulated by binding proteins, which from a risk standpoint means sustained free IGF-1R activation without the IGFBP buffering system that modulates native IGF-1 activity in healthy physiology