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Owing to its distinctive distribution features, paracrine functions, and metabolic traits, EAT has garnered extensive attention as an imaging biomarker for metabolic and cardiovascular diseases, serving as a transducer that conveys the cardiotoxic effects induced by chronic inflammation and metabolic disturbances (18)

Common side effects include nausea, vomiting, and gastrointestinal upset, typically managed through slow titration

In Ozempic drug trials, significant weight loss was noted amongst participants, and this drug was later developed and approved as a weight loss medication (named Wegovy)

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[40] reported that exendin-4 increased LXR-mediated ABCA1 expression through AMPK activation, improving cholesterol-induced toxicity in INS-1 cells