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Current reviews in musculoskeletal medicine, 18(12), 611-619

Women eating a vegetarian diet have a three-fold increase in fecal estrogen excretion and have lower serum estrogen levels by 15%-20%.[3] Intestinal dysbiosis, or an imbalance of the gut microflora, may also contribute to estrogen dominance

J Neuroinflammation 15(1):245 Jing F, Zhang Y, Long T, He W, Qin G, Zhang D, Chen L, Zhou J (2019) P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine

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A manufacturer that already works extensively with natural ingredients is well positioned to create these types of hybrid formulations