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More serious risks are rare but can include complications such as inflammation of the pancreas or gallbladder problems

This phenomenon has been corroborated by autopsy findings in PD patients, which reveal a significant presence of activated microglia in the substantia nigra and basal ganglia regions of their brains, whereas microglia in the brain tissue of healthy individuals remain in a quiescent state (He et al., 2018)

Finally, another layer of complexity is added when considering the evidence of a leaky bloodbrain barrier across several neuropsychiatric disorders 255 , which could further increase the brain penetrance of GLP-1RAs administered to people with such illnesses

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