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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Ren Z, Jia G, He H, et al

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In a meta-analysis of 40 studies, people with the 677 TT genotype had a strikingly similar 16% higher odds of coronary heart disease compared with those with the CC genotype: These results support the hypothesis that impaired folate metabolism, resulting in high homocysteine levels, is causally related to increased risk of CHD